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Enthalpy

Enthalpy is predominately driven by intermolecular forces or noncovalent interactions that occur between molecules or parts of the same molecule without forming a chemical bond. Although weaker than covalent bonds, these interactions are fundamental to the binding of drugs to their targets and the overall stability of molecular complexes.

  1. Chapter 5 of Rosa, J. M. C. (2023). Pharmaceutical Chemistry: Drug Design and Action. Walter de Gruyter GmbH & Co KG. ↩

  2. Chapter 5 of Rudrapal, M., & Egbuna, C. (Eds.). (2022). Computer aided drug design (CADD): From ligand-based methods to structure-based approaches. Elsevier. ↩

  3. Chapter 2 of Kumar, T. D. A. (2022). Drug Design: A Conceptual Overview. CRC Press. DOI: 10.1201/9781003298755 ↩

  4. Chapter 2 of Cooksy, A. (2014). Physical Chemistry: Thermodynamics, statistical mechanics, and kinetics. Pearson. ↩

  5. Chapter 2 of Jensen, F. (2017). Introduction to computational chemistry. John wiley & sons. ↩

  6. Chapter 2 of Strømgaard, K., Krogsgaard-Larsen, P., Madsen, U. (2017). Textbook of drug design and discovery. CRC Press. ↩

  7. Chapter 10 of Cooksy, A. (2014). Physical Chemistry: Quantum chemistry and molecular interactions. Pearson. ↩

  8. Chapter 1 of Stone, A. J. (2013). The theory of intermolecular forces. Oxford University Press. ↩

  9. Chapters 3 - 4 of Anslyn, E. V., & Dougherty, D. A. (2006). Modern physical organic chemistry. University science books. ↩